An updated and comprehensive reference to pathology in every organ system in genetically modified mice

The newly revised and thoroughly updated Second Edition ofPathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice.

The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice.

Readers will also benefit from:A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant miceAn exploration of concepts related to validating animal models, including the Cinderella EffectPractical discussions of basic necropsy methods and grading lesions for computational analysesConcise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues

As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

The editors

John P. Sundberg, DVM, PhD, DACVP, is Professor at The Jackson Laboratory in Bar Harbor, Maine, USA and an Adjunct Professor in the Department of Dermatology, Vanderbilt University Medical Center in Nashville, TN, USA.

Peter Vogel, DVM, PhD, DACVP, is Director of the Veterinary Pathology Core Laboratory at St. Jude Children's Research Hospital in Memphis, Tennessee, USA.

Jerrold M. Ward, DVM, PhD, DACVP, FIATP,is an Adjunct Faculty member at The Jackson Laboratory, Bar Harbor, Maine, USA and Adjunct Professor in the Department of Biomedical Sciences at Cornell University College of Veterinary Medicine in Ithaca, New York, USA.

List of Contributors vii

Preface and Acknowledgments x

1 Introduction to Mouse Pathology 1
Jerrold M. Ward, Peter Vogel, and John P. Sundberg

2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research 6
Dale A. Begley, Paul N. Schofield, and John P. Sundberg

3 Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics 22
John P. Sundberg, Dale A. Begley, Melissa L. Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield

4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect 39
John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofield

5 Embryos, Placentas, and Neonates 48
Brad Bolon and Jerrold M. Ward

6 Ciliopathies 72
Peter Vogel and Laura J. Janke

7 Hematopoietic and Lymphoid Tissues 82
Harm HogenEsch and John P. Sundberg

8 Mouse Hematolymphoid Neoplasms 97
Jerold E. Rehg

9 Immunodeficient and Humanized Mice 132
Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEsch

10 Skin, Hair, and Nails 159
John P. Sundberg, Lloyd E. King, Jr, and Raoul V. Kuiper

11 Mammary Gland 213
Alexander D. Borowsky and Robert D. Cardiff

12 The Respiratory Tract 237
Jerrold M. Ward and John P. Sundberg

13 The Gastrointestinal Tract 259
Jerrold M. Ward, Piper M. Treuting, and M. Kay Washington

14 Cardiovascular System 284
Kathleen L. Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy K. Cooper

15 Liver and Pancreas 307
Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger

16 Neuromuscular System 336
Peter Vogel, Laura J. Janke, and Heather W. Sheppard

17 Endocrine System 355
Krista M. D. La Perle

18 Kidney and Urinary Bladder 378
Jeffrey B. Kopp, Avi Z. Rosenberg, Cory F. Brayton, Jeffrey I. Everitt, and Jerrold M. Ward

19 Female Reproductive System 403
Darlene Dixon and Alexander Yu. Nikitin (In Memory of Dr. Joel Mahler)

20 Male Reproductive System 431
Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, and Robert D. Cardiff

21 Nervous System 462
Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli

22 Eye and Ear 493
Heather W. Sheppard, Laura J. Janke, Jerold E. Rehg, and Peter Vogel

23 Bones and Teeth 520
Peter Vogel, John P. Sundberg, and Cheryl Ackert-Bicknell

Index 541